That honor likely goes to leptin.

It appears that the hormone leptin is largely responsible for the accuracy of insulin signaling and whether one becomes insulin resistant or not.

Leptin, a relatively recently discovered hormone produced by fat, tells the body and brain how much energy it has, whether it needs more (saying "be hungry"), whether it should get rid of some (and stop being hungry) and importantly what to do with the energy it has (reproduce, upregulate cellular repair, or not). Recent compelling research reveals that the two most important organs that will determine whether one becomes (type 2, insulin resistant) diabetic or not are the liver and the brain and it is their ability to listen to leptin that will determine this.

Leptin largely influences, if not controls, the manifest functions of the hypothalamus in the brain, including:

Reproduction, Thyroid function, Adrenal function and the Sympathetic nervous system.

Fat, and leptin, strongly influences chronic inflammation and therefore diseases associated with this including heart disease, Alzheimer's, and diabetes.

It appears now that rather than your brain being in control of your body, fat, by way of leptin, is really in the driver's seat.

The Enemy Is Not Only Foreign To The Medical Community; It Appears To Not Even Be Recognized.

It is no wonder that (type 2) diabetes has not been conquered.

By some estimates, diabetes has increased over 700% in the last 50 years.

This reveals two very important facts.

Diabetes cannot be primarily a genetic disease, since the prior statistic has taken place within the same generation and presumably essentially the same genetics.

Something that we have been doing is obviously wrong and needs to be changed.

That something is diet.

It is difficult, or perhaps even impossible, to actually prove that something is true.

However, it is not difficult to prove that something is false.

Americans have been following (at least partially), for the last 50 years, the nutritional recommendations of a high complex carbohydrate, low saturated fat diet from the:

American Dietetic Association, American Heart Association, and the American Diabetes Association.

That, in itself, is an oxymoron since most of those "complex" carbohydrates, such as potatoes, rice, cereals, pasta, and breads rapidly turn to sugar and the excess sugar (glucose) rapidly turns into long-chain saturated fatty acids (palmitic acid; "palm oil").

Concomitant with that recommendation the incidence of diabetes and obesity has skyrocketed and has become one of the worst worldwide epidemics the world has ever seen.

Eating a high "complex" carbohydrate, low saturated fat diet for health and longevity has been shown, and perhaps even "proven," to be wrong.

Minimal common sense would say to try something else.

Diabetes Is A Disease Of Nutrition, And It Is The Science Of Nutrition That Must Treat It.

Science is telling us that we must eat a diet that maximizes the accuracy of insulin and leptin signaling allowing cells, you, to better listen to their life-giving messages. (The need for those hormones to have to "yell" to be heard is reduced and the levels of insulin and leptin are therefore lowered.)

That would be the eating plan emphasizing good fats and reduced nonfiber carbohydrates/starches as outlined in my book "The Rosedale Diet" and Dr. Mercola's "Total Health Program".

Doing so will greatly improve and even reverse type 2 "insulin resistant" diabetes, heart disease, hypertension, many other chronic diseases of aging, and even aging itself, as many of my patients who have been able to totally eliminate the use of their drugs, including insulin, can attest.

Following those guidelines will let you -- and your genes -- "be the best that you can be.

source - Ron Rosedale